We assessed the presence and characteristics of the intracellular pathogen Chlamydophila (Chlamydia) pneumoniae in brain-tissue samples from 25 patients with late-onset Alzheimer’s disease (AD) and 27 non-AD control individuals. “Does it play a job within the mind, or is it simply rubbish that accumulates,” asks Rudolph Tanzi of Harvard Medical College. Some toxins are released from bacteria when they die and may cause shock and fever. Except that catching Chlamydia pneumonia has extremely serious consequences. Mark Ide from the college where the tests were performed said he was “surprised” by the rate of decline. However, they do hint that microbes might seed plaques, which could indirectly explain why different pathogens have been tied to AD. The strategy might work for other disorders characterized by mitochondrial dysfunction, such as amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease, suggest the researchers.
And according to study author Rudolph E. Ce sont eux qui seraient responsables de l’accumulation des plaques amiloïdes « collantes » et du mauvais repliement des protéines tau dans le cerveau humain. The herpes virus in particular is known to damage the central nervous system, and the limbic system in the brain which regulates mood and instinct and is associated with mental decline and personality changes. Strong evidence is also unfolding for other diseases Epidemiologists have found that a majority of heart disease patients have been infected with a common bacterium, and Canadian researchers recently reported a mechanism by which it could trigger heart disease. These agents are treatable by diet and drugs, vitamin supplementation, pathogen detection and elimination, and autoantibody removal, although again, the beneficial effects of individual treatments may be tempered by genes and environment. “There’s a tipping point,” he said, but no one yet knows where that is. Poor oral hygiene and gum disease both lead to the inflammation of gums as well as a build-up of bacteria.
Alzheimer’s researchers had always considered amyloid to be “junk,” involved only in destructive activities, but Moir said he thought amyloid must also have a positive role, because animals have had it for 400 million years. Alzheimer’s researchers had always considered amyloid to be “junk,” involved only in destructive activities, but Moir said he thought amyloid must also have a positive role, because animals have had it for 400 million years. The reason why there may be an association, the researchers suggest, is because viruses have been linked with certain cancers and some bacteria are associated with stomach ulcers; the connection between microorganisms and types of diseases is not uncommon. In 1991, Ruth Itzhaki, Ph.D., professor emeritus of molecular neurobiology at Britain’s University of Manchester, and colleagues first linked the disease to herpes simplex virus 1 (HSV-1), which is the type that causes cold sores. Inflammation is an extreme threat to brain health. The accumulating research that suggests Alzheimer’s disease may have an infectious component is becoming too plentiful to ignore. In addition to viruses, bacteria and fungus, an infectious protein called TDP-43 has also been linked to the disease.
Accompanying increases in proinflammatory marker transcript levels was a concomitant enhancement in the number of microglia/macrophages and intracellular Aβ42 accumulation in the hippocampi of rAAV1-IFNγ-injected 3×Tg-AD mice.