Herpesvirus infections rarely cause significant problems in the immunocompetent human host. The herpes simplex virus type 1 (HSV-1) TK was similarly expressed for comparison. Here we identified two roles for EBNA1 in the reactivation of latent EBV to the lytic cycle in epithelial cells. The geometric mean titres against CMV and HSV were also slightly higher in GBS compared with controls, but no titre variations were observed. Cohen received his M.D. To determine whether these arginines function as an ER/nuclear localization signal, point mutants were constructed differentially substituting the four arginines. The HSV-1 polymerase was more sensitive than the EBV DNA polymerase to inhibition by phosphonoacetate, phosphonoformate, aphidicolin and N-ethylmaleimide.
The green arrow indicates the rotation of domain IV, also illustrated in A. Infection by cytomegalovirus (CMV) is the major cause of morbidity and mortality in individuals with depressed cell mediated immunity of congenital origin, iatrogenic origin and that associated with acquired immunodeficiency syndrome (AIDS). The observation of varying serum antibody titres against EBV during the course of GBS can be interpreted as primary infections or as manifestations of reactivated latent virus infections. CONCLUSION: children’s tonsils can be colonized by EBV and such colonies may be associated with the pathogenesis of recurrent tonsillitis.