Antibody response to varicella-zoster virus surface glycoproteins in chickenpox and shingles. – PubMed

Antibody response to varicella-zoster virus surface glycoproteins in chickenpox and shingles. - PubMed

Antibody response to varicella-zoster virus surface glycoproteins in chickenpox and shingles. - PubMed
Antibody titers to varicella-zoster (VZ) virus in persons aged 1-85 years were measured. Serum samples were assayed for specific varicella-zoster virus (VZV) IgG antibodies using a commercial enzyme-linked immunosorbent assay kit. All patients with herpes zoster showed high or moderate titers of both Pl.A.- and CF-reactive VZV antibodies. Varicella-zoster virus (VZV), a herpes virus, causes 2 exanthematous (rash-associated) diseases, chickenpox and herpes zoster (shingles). VZV-specific IgA and IgG antibody titers demonstrable by ACCA were compared with those measured by solid-phase indirect enzyme immunofluorescence assay (EIFA). Pediatricians had lower levels of circulating CD4+-naive T cells and showed boosting of CD8+ effector memory T cells. wt.

The IgG responses to these glycoproteins during various clinical circumstances are described. In acute sera from all chickenpox patients and in the majority of acute shingles sera, antibodies reactive with glycoproteins could not be detected. The findings with the Pl.A. The infection in pregnant women may spread through the placenta to the fetus, causing congenital disease in the infant. Links to PubMed are also available for Selected References. The secondary immune response in humans, elicited after reexposure to a virus or other pathogens, can reinforce the quantity and quality of the immune response against the challenging pathogen. Disseminated zoster was associated with significantly low levels of antibodies to these surface glycoproteins.

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