Bell’s palsy and herpes simplex virus. – PubMed

Bell's palsy and herpes simplex virus. - PubMed

Bell's palsy and herpes simplex virus. - PubMed
^ a b c d e f g h i j k l m n o p q r s t u Aguirre, A. This likely reflects that fact that IPF acute exacerbations are defined clinically as “noninfectious,” and little attention has been paid to the outcomes of patients with IPF with diagnosed infections. Many underlying mechanisms that infectious diseases cause atherosclerosis have been proposed; most of them suggested that inflammatory process provoked by infectious diseases led to atherosclerosis. Most spindle cells in an advanced KS tumor are latently infected, but a small minority of cells express lytic markers (17, 68, 69, 84). In our opinion, the possible link between Bell’s palsy and HSV can only be explored properly by studying the human facial nerve, and especially the geniculate ganglion itself. Animal modeling has been used to better understand how a gamma herpesvirus infection can modulate the pathogenesis of lung fibrosis and has demonstrated that preceding infections appear to reprogram lung epithelial cells during latency to produce profibrotic factors, making the lung more susceptible to subsequent fibrotic insult, whereas exacerbations of existing fibrosis, or infections in susceptible hosts, involve active viral replication and are influenced by antiviral therapy. Full text Full text is available as a scanned copy of the original print version.

METHODOLOGY: We evaluated 38 patients with Bell’s palsy submitted to anamnesis, clinical and ENT examination and saliva sampling for viral DNA detection by PCR technique. The detection of HSV-specific latency-associated transcripts in the ganglia of control patients provided further evidence for the hypothetically latent state of HSV in the geniculate ganglia in these patients. Recent PCR experiments performed by a Japanese group strongly suggest that the area adjacent to the geniculate ganglia does not usually contain any HSV at all, except in patients with Bell’s palsy. Complete: Journals that are no longer published or that have been combined with another title. Consequently, it has been suggested that “Bell’s palsy” be renamed as “herpetic facial paralysis”.

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