Comparison of Intrathecal Concentrations of Acyclovir following Epidural and Intravenous Administration in Rats. – PubMed

Comparison of Intrathecal Concentrations of Acyclovir following Epidural and Intravenous Administration in Rats. - PubMed

Comparison of Intrathecal Concentrations of Acyclovir following Epidural and Intravenous Administration in Rats. - PubMed
Acyclovir is an antiviral agent against herpes virus. Acyclovir infusion was given in a dose of 5 mg/kg/every eight hours. Each capsule of acyclovir contains 200 mg of acyclovir and the inactive ingredients colloidal silicon dioxide, croscarmellose sodium, magnesium stearate and microcrystalline cellulose. Five of the seven patients showed some return of facial function at the time of discharge. infusion over 1 h, 20 mg of acyclovir/kg administered as tablets by nasogastric intubation, and 20 mg of valacyclovir/kg administered as tablets by nasogastric intubation. Group Epi was further subdivided into 3 groups according to acyclovir dosage; each group comprised 5 animals receiving injections at dosages of 0.3 mg, 0.6 mg, and 0.9 mg. Group IV was also subdivided into 3 groups receiving dosages of 3 mg, 6 mg, and 9 mg.

At the fifteenth day of treatment, a necrotic and bullous eruption occurred on the left leg adjacent to the infusion site []. In Group Epi, the median plasma concentrations of acyclovir were lower than that in CSF (P < 0.05). This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The CSF concentrations of acyclovir in Group Epi were significantly higher than that in Group IV (P < 0.05). The i.v. There were no references of equivalent dosages of acyclovir between IV and epidural administration. However, it is obvious in this study that epidural administration of a low dose of acyclovir can more effectively increase its concentration in the intrathecal space than IV administration.

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