Drug-induced pemphigoid is the term used to describe cases presenting with clinical, histologic, and immunopathologic findings similar to idiopathic (autoimmune) pemphigoid but where the lesions develop subsequent to taking a drug. It is particularly important to read the symptoms of a blood clot – see section 2 “Blood clots”. We screened specimens of clinically normal skin from nine junctional epidermolysis bullosa patients (3 GABEB, 4 lethal, 1 cicatricial, 1 pretibial) by immunofluorescence using monoclonal antibodies to the 180-kD and 230-kD bullous pemphigoid antigens (BP180 and BP230). Loss of basal cells (stratum basale) — key feature. Flare-ups are common 24 to 48 h postpartum and can occur during subsequent menses or ovulation. Both types of herpes cycle between active outbreaks — where blisters are present — and inactive cycles, where the virus goes into remission. Bullous skin diseases may be acquired or induced or they may be autoimmune in origin.
Certaines lésions sont en cocarde. Conclusions IgA-specific antibodies against BP180 were detected in all our patients. For the selection of the type of medication as well as rules of life depends on the decision of the doctors based on the disease condition. However, dermal reactions correlated poorly with EBA, with some serum samples from BP patients binding to dermal-side antigens. Les lésions prennent l’aspect de cocardes centrées par une bulle et se répartissant sur les mains, les coudes, les genoux et le dos. Typically, patients have a few scattered erosions or tense blisters on a red or urticarial base. Binding of IgG autoantibodies to desmoglein 3 causes acantholysis by interfering with the adhesion of adjacent desmogleins, without the participation of other inflammatory events.
Parmi les traitements les plus souvent incriminés, on retrouve les sulfamidés, les barbituriques, les anti-inflammatoires non stéroïdiens etc. Initially, vesicles develop which rapidly enlarge to become bullae. These include scabies, pityriasis rosea, drug rashes, and cutaneous infections that, as a first step, should be excluded. Ces lésions bulleuses sont généralement cicatricielles puisqu’elles laisses des kyste en disparaissant.