Detection of four lymphotropic herpesviruses in Hungarian Patients with multiple myeloma and lymphoma – Csire – 2006 – FEMS Immunology & Medical Microbiology

Detection of four lymphotropic herpesviruses in Hungarian Patients with multiple myeloma and lymphoma - Csire - 2006 - FEMS Immunology & Medical Microbiology

GöTTINGEN, Germany – July 23, 2014 – PRLog — Description ELISA-VIDITEST and IF-VIDITEST anti-HHV-6 kits are intended for serological diagnosis of diseases associated with HHV–6 infection, such as exanthema subitum, acute respiratory illnesses, diarrhoea with fever and febrile seizures in infants, heterophile antibody-negative infectious mononucleosis in children, also interstitial pneumonia, encephalitis, meningitis, hepatitis, and aplastic anemia in immunodeficient patients. Recently, human herpesvirus 6 (HHV-6) reactivation has been observed frequently in patients with DIHS/DRESS, but not in SJS/TEN (3–5). Main Outcome Measures  The results of serologic tests for antibody titers for various viruses, including HHV-6, HHV-6 DNA detection by real-time polymerase chain reaction, immunoglobulin levels by turbidimetric immunoassay, IgG subclass levels by nephelometry, and CD19+ B-cell counts by flow cytometric analysis, were sequentially assessed. In order to know if there is an active HHV-6 infection in CFS patients we studied the immunologic and virologic status of HHV-6. The pathogenesis of SJS is thought to be initiated by an immune response to an antigenic complex formed by drug metabolites or microorganisms. She was born at 39 weeks’ gestation and weighed 3.0 kg. 72.0%; p = 0.0004) and CMV (67.7% vs.

Detection of four lymphotropic herpesviruses in Hungarian Patients with multiple myeloma and lymphoma - Csire - 2006 - FEMS Immunology & Medical Microbiology
The prevalence in France (76%) was similar to previous results from other European countries. However, to date there is no validated assay to determine HHV6 antibody responses. Human herpesvirus-8 (HHV-8) has been discovered in lesions of Kaposi’s sarcoma (KS) patients and has already been proved to be the causative agent of both sporadic and HIV-associated forms of the disease (Chang et al., 1994; Corbellino et al., 1996). Latent infection of bone marrow stromal cells by HHV-8 has been implicated in the development of multiple myeloma (MM) as well as in the conversion of MGUS (monoclonal gammopathy of unknown significance) into full-blown myeloma (Parravicini et al., 1997; Ma et al., 2000; Hermouet et al., 2003; Fonseca et al., 2004). Physical examination revealed high fever and haemorrhagic erosions on the lips, oral mucosa (Fig. There is a noticeable dichotomy in the results published, certain groups consistently producing data to affirm and others to refute the hypothesis of viral involvement (Kikuta et al., 1997; Parravicini et al., 1997; Mikala et al., 1999; Leāo et al., 2002; Barillé-Nion et al., 2003; Fonseca et al., 2004). One important question has not been raised in connection with the pathogenesis of gamma herpesviruses.

An 18-year old female with a history of recurrent oral and genital HSV outbreaks presented with fever, malaise and myalgias, and subsequently developed 60% total body surface area involvement with target lesions, extensive erythematous plaques, bullae involving her face, neck, arms, chest, abdomen and proximal extremities as well as epithelial defects and pseudomembrane involvement of both conjunctivae. The conditioning regimen consisted of 4 mg/kg per day of targeted oral BU on days −8 to −5, 60 mg/kg of etoposide on day −4 and 60 mg/kg per day of CY on days −3 to −2. The aim of the current study was to test the simultaneous presence of four different lymphotropic herpesviruses in Hungarian MM patients, Waldenström’s macroglobulinemia (WM) and MGUS. We are aware that molecular differences have been found in the HHV-8 viruses of MM and KS patients (Ma et al., 2000). The possible role of different herpesviruses, such as HHV-8, in the etiology and pathogenesis of monoclonal gammopathies has been addressed by several groups, yet the systematic complex search for involvement of multiple lymphotropic herpesviruses has not yet been discussed. In this study serology and nested PCR techniques were used for the detection of the viral genomes and specific immunologic responses of Epstein-Barr virus (EBV also known as HHV-4), human cytomegalovirus (CMV or HHV-5), human herpesvirus-6 (HHV-6) and HHV-8 in bone-marrow aspirates and peripheral blood samples of all MM patients. Similar samples of patients diagnosed with different types of non-Hodgkin’s lymphoma (NHL) were used as control (Corbellino et al., 1996).

A skin biopsy obtained from the left thigh showed epidermal necrosis and subepidermal blisters.

You may also like