Effect of combinations of acyclovir with vidarabine or its 5′-monophosphate on herpes simplex viruses in cell culture and in mice.

Effect of combinations of acyclovir with vidarabine or its 5'-monophosphate on herpes simplex viruses in cell culture and in mice.

Effect of combinations of acyclovir with vidarabine or its 5'-monophosphate on herpes simplex viruses in cell culture and in mice.
In persons with suspected acyclovir-resistant HSV, viral culture of the lesion should be performed, and if virus is isolated, susceptibility testing done to confirm drug resistance (AII). In addition to describing safe and effective ACV treatment, published case reports have described the isolation of ACV-resistant (ACVr) viruses, predominantly from immunocompromised patients and, in only five cases, from immunocompetent individuals (14, 23, 24, 32, 38, 39). However, during HSV infections, mutants arise that are acyclovir resistant primarily because they lack viral TK activity (TK−) and do not phosphorylate acyclovir.2 In non-immunosuppressed HSV-infected individuals treated with acyclovir, wild-type TK + HSV is inhibited by acyclovir, and the small amounts of TK− HSV that develop are likely controlled by the immune system. A diagnosis of herpes simplex encephalitis was confirmed in 42 patients. Delays in starting treatment are associated with poorer clinical outcomes. Furthermore, in the presence of the two drugs, mutants resistant to vidarabine, acyclovir, or vidarabine/acyclovir could not be isolated. No important or new adverse events were recognised.

نمونه های مایع ResultsIntra چشم بیماران HSV-1 یووئیت شامل HSV-1 quasispecies، عمدتا متشکل از یک بیمار خاص جزئی انواع عمده و چند مربوط ژنتیکی TK. Get a printable copy (PDF file) of the complete article (1.3M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

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