Effect of valacyclovir on viral shedding in immunocompetent patients with recurrent herpes simplex virus 2 genital herpes: a US-based randomized, d… – PubMed

Effect of valacyclovir on viral shedding in immunocompetent patients with recurrent herpes simplex virus 2 genital herpes: a US-based randomized, d... - PubMed

Effect of valacyclovir on viral shedding in immunocompetent patients with recurrent herpes simplex virus 2 genital herpes: a US-based randomized, d... - PubMed
RIYADH, 30 April 2003 — Genital herpes is a viral infection caused by the herpes simplex virus or HSV. But many doctors are puzzled because the operation doesn’t carry a 100 percent guarantee, it’s major surgery — and women have other options, from a once-a-day pill to careful monitoring. Reactivation from latency with concomitant virus production is an efficient means of viral spreading within the population. Daily genital and anal or rectal swabs were self-collected during the 60-day study period for evaluation of HSV-2 viral shedding as determined by quantitative type-specific polymerase chain reaction assay. A person who has genital herpes infection can easily pass or transmit the virus to an uninfected person during sex. Matthew Golden and Judith Wasserheit of the University of Washington wrote in an accompanying editorial. Herpes keratitis is the leading infectious cause of blindness in the United States and is caused predominantly by HSV-1, with a reported incidence of 149 cases per 100,000 individuals and, cumulatively, up to 500,000 cases per year.

In the intent-to-treat population, a 71% reduction in total shedding (P < .001), a 58% reduction in subclinical shedding (P < .001), and a 64% reduction in clinical shedding (P = .01) were observed. Both HSV-1 and HSV-2 can produce sores in and around the vaginal area, on the penis, around the anal opening, and on the buttocks or thighs. The American Academy of Pediatrics previously said there was not enough evidence to recommend routine circumcision of infants.

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