Erythema multiforme (EM) is an extremely rare condition in infancy. Get a printable copy (PDF file) of the complete article (290K), or click on a page image below to browse page by page. The main cause is the herpes virus, either as a cold sore, genital herpes, or as a hidden infection. Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program, San Diego, California. Erythema multiforme (pronounced: air-uh-THEE-muh mul-tuh-FOR-me) is a rash that forms in reaction to an infection. We recommend a trial of oral acyclovir in cases of severe EM caused by recurrent HSV. Erythema multiforme (EM) is an immune-mediated, mucocutaneous condition characterized by “target” lesions.1 Classically, EM has been separated into 2 subgroups: EM without mucous membrane involvement (EM minor) and EM with mucous membrane involvement (EM major).
Although this did not follow neural dermatomes, it did have a dermatomal-like pattern (Figure 1). If it were caused by a medication, the drug would need to be stopped. The epidermis of the skin peels off in sheets greater than 3 cm, and the skin becomes tender within 48 hours. Most cases are not preventable. Toxic Epidermal Necrolysis (TEN) is the most severe vesiculobullous disease along this spectrum. This condition is usually diagnosed by its appearance. Skin grafting may be helpful in cases in which large areas of the body are affected.
This involves taking a small piece of skin with a special tool. This piece can then be analysed to make the diagnosis. Here, we report a case of EM in a neonate. Scarring or infection of the skin, vision problems, scarring in the gut, and even death may result from severe forms of this condition. Oral Aciclovir may be prescribed to help prevent recurrences. stopping the medication causing the problem treating the infection causing the reaction medications to help the skin heal medications to reduce inflammation in the eye treating complications, such as a skin infection What are the side effects of the treatments? Occasionally, doctors won’t know what caused the rash to develop, but still can help someone heal.
These may include allergic reactions, stomach upset, and other side effects. Specific side effects depend on the drugs used. The vesicles became bullae and coalesced. Most people recover without a problem and can return to normal activities. In most series, some cases remain idiopathic. If caused by herpes, a person may want to consider taking drugs to prevent further herpes outbreaks. Interestingly, although most report no sex predilection, this group found that women were more likely to have TEN and men SJS.
How is the condition monitored? In mild cases, the skin is monitored until the rash disappears, usually by the affected person at home. In serious cases, a person may need to be admitted to the hospital for closer monitoring. The doctor in this setting often does repeated examinations. These findings were compatible with the diagnosis of erythema multiforme.