The World Health Organization estimates that 536 million people aged 15–49 are infected with Herpes simplex virus type 2 (HSV-2), the causative agent of genital herpes. In JH2604, a 1.5 kbp deletion extends from the DR1/Ub junction of the ‘a’ sequence to 511 bp upstream of the 5′ end of IE1 in both long repeats. 69) was found to produce a large number of morphologically normal, but noninfectious, particles; under nonpermissive conditions, these mutant particles were able to interfere with the replication of wild-type HSV-2. Focus formation in 1% serum and neoplastic transformation were observed in cells exposed to virus inactivated before infection, but the frequency was enhanced (15- to 27-fold) in cells in which the virus was inactivated at 4 to 8 h postinfection. RESULTS: Dried blood spots were collected for 80% of the 1607 participants in the survey who reported that they were sexually active. In conclusion, the prevalence of HSV-2 varied significantly according to the socio-demographic and geographic characteristics of the adult population in Mexico. Seroprevalence among schools ranged from 0 to 57%.
The number of sex workers registered in the locality was the most important covariate of seroprevalence, with each additional female sex worker (FSW) per 1000 women between 18 and 45 years of age in the town associated with an increase of 1% in the seroprevalence of HSV-2. CONCLUSIONS: Characteristics of adolescents’ micro-environments that influence their pool of potential sexual partners and the likelihood that these partners are HSV-2 positive may be more important predictors of the risk of STI infection than self-reported condom use.