Intermediate filaments (IF) are essential to maintain cellular and nuclear integrity and shape, to manage organelle distribution and motility, to control the trafficking and pH of intracellular vesicles, to prevent stress-induced cell death, and to support the correct distribution of specific proteins. Gene transfer into mammalian central nervous system using herpes virus vectors: Extended expression of bacterial lac Z in neurons using the neuron-specific enolase promoter. Therefore, wild-type mice as well as mice with various combined genetic deficiencies in the alpha/beta interferon receptor or gamma interferon receptor and in the ability to produce mature B and T lymphocytes (RAG-2 deletion) were infected with BHV-1 and BHV-5 and monitored clinically, serologically, histopathologically, and virologically. Up to now, two variants of this virus have been identified, A and B, which differ in genetic, biological and immunological characteristics. Herpes Simplex Virus type-1 (HSV-1) was the most frequently detected virus (56.25%), followed by Cytomegalovirus (CMV) (37.5%). These interactions, either known or potential, will be the focus of this review. Virol.
In contrast, the same mice succumbed to neurological disease and death upon infection with BHV-5. Presence of DNA sequences of this virus in mononuclear cells of peripheral blood, skin and plasma of pityriasis rosea patients, points to possible connection between this illness and HHV-7 infection.