Two-thirds of the world’s population under 50 have the highly infectious herpes virus that causes cold sores around the mouth, the World Health Organization said on Wednesday, in its first estimate of global prevalence of the disease. In India, most studies of HSV-2 and syphilis incidence are in high-risk populations and may not accurately reflect infectious activity. The invasive species now comprise 80% of all fish in southern Australia’s Murray-Darling river system, up from 58% four years ago, in a region that produces a third of the country’s total agricultural output. Cases (n=1,108,986) were people with first cancers identified in cancer registries (1992-2005). It ends up being over 80%+ of the population will have it. After calculating sexually transmitted infection (STI) incidence, associated factors were assessed using modified Poisson regression and within-couple transmission rates modelled using seroconcordance/discordance data. Viruses introduced to kill rabbits in Australia have had limited success.
Results: HZ prevalence was modestly higher in cases than controls (1.4% vs. If people here claiming that they are disgusted got tested, they might be surprised with the results. We identified significant associations between HZ and oral cavity/pharyngeal (adjusted odds ratio [aOR]=1.21), colon (aOR=1.10), lung (aOR=1.11), and non-melanoma skin (aOR=1.46) cancers; myeloma (aOR=1.38); diffuse large B cell lymphoma (aOR=1.30); lymphoplasmacytic lymphoma (aOR=1.99); and chronic lymphocytic leukemia/small lymphocytic lymphoma (aOR=1.55). Tests by Australia’s main science agency, which has been researching the virus at a quarantine lab for the past seven years, have shown the koi herpesvirus CyHV3 could kill four in every five carp that become infected. Associations were strongest when HZ was diagnosed 13-35 months before cancer diagnosis/selection; they were significant for some cancers in the 36-59-month period, and 60+ months for lymphoplasmacytic lymphoma (OR=1.99). There are bio techs working on a vaccine atm including an Australian one lead by former Australian of the year Dr Ian Frazer. Associations were strongest at short latency intervals for many cancers, and for regional/distant stages among solid cancers, perhaps reflecting reverse causality.
Impact: Age-related immune decline does not play a major role in cancer development in older people, but it may be important for some lymphomas.