Herpesvirus Envelopment

Herpesvirus Envelopment

Herpesvirus Envelopment
Sjögren’s syndrome (SS) is an autoimmune exocrinopathy associated with multiple autoantibodies, lymphocyte infiltration of various organs, and functional deficiency of T cells. (Baylor University College of Medicine, Houston, Texas) and Lucy Rasmussen. The study involved 44 children who were recipients of allogeneic HSCT and who were grafted between January 1994 and December 2005. Study design: Salivary glands biopsies from 55 patients suffering of primary and SS syndrome were explored by herpesviruses consensus PCR primers and all the PCR products were sequenced. However, when wt-p53 gene combined with HSV-tk/GCV system, the killing effects was significantly stronger (P < 0.05) and the cell survival rate decreased to 20%. Among 60 paraffin blocks salivary gland tumors with equal chances of presence of the HHV-7 and HHV-6 in the samples, 34% were positive for both HHV-7 and HHV-6 while 47.2% were only positive for HHV-7, 18.9% samples were positive for HHV-6. The Dr wants to remove the gland. Among the 15 cases with paired samples, 9 were HHV-8-positive for both samples, 4 were HHV-8-negative for both samples while in two cases HHV-8 was detected only in the tumor specimens. CONCLUSIONS: HHV-8 is frequently detected in adenoid salivary neoplasms, suggesting a significant role of the virus in the etiopathogenesis of the disease. EBV was detected in all eight cases, especially in nasal mucosa, tonsil, spleen, lymph node, tongue, and intestine, but in only two of six whole-blood specimens. Current treatments for hyposalivation are limited to (i) patient education, diet, and lifestyle modifications; (ii) prevention of dental and oral mucosal diseases; (iii) management of symptoms; (iv) sialogogues or salivary gland stimulants (e.g., the muscarinic receptor agonists pilocarpine and cevimeline) that induce saliva secretion from residual acinar cells (Vissink et al, 2010); and (v) use of artificial saliva (Silvestre et al, 2009).

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