FHV – Feline herpesvirus – rozprzestrzenia się łatwo. Epizootic outbreaks of virulent systemic disease (VSD) have been reported in the USA and Europe. Detection rates were calculated by assuming that any sample in which FHV-1 DNA was detected was a true-positive result. Severe ocular lesions including conjunctivitis were found in the cats infected with the isolates, indicating that the recent FHV-1 has a potential to induce severe FVR symptoms including ocular lesions. There was no detectable FHV-1 DNA in the VL of any cat. Among 22 cats, 20 were qPCR positive for FHV-1, 7 for M. The virus frequently remains latent in the nerve tissue in the head (trigeminal ganglia), from where it can reactivate.
On the other hand, gp143/108 contained only one antigenic site consisting of 5 similar or overlapping epitopes, one of which seemed to be a conserved region recognized by all MoAbs reacting to this protein. Therefore, the physical structure of the FHV-1 genome is similar to the genomes of other alpha-herpesviruses. Nine cats were positive for two or more pathogens. Histopathologic lesions were present in all cats, with consistent lesions in the nasal cavity, including acute necroulcerative rhinitis in 16 cats. Performance of the study was approved by the Clinical Review Board of the Department of Clinical Sciences, Colorado State University. No lesions that could be specifically attributed to FCV, M. felis, or C.
felis were seen, although interpretation in this cohort could be confounded by coinfection with FHV-1. A significant agreement was found between the amount of FHV-1 DNA determined by qPCR and the presence of specific histopathologic lesions for FHV-1 but not for the other respiratory pathogens.