[Human herpes virus 6 infection in renal transplant recipient–case report]. – PubMed

[Human herpes virus 6 infection in renal transplant recipient--case report]. - PubMed

In order to assess the full spectrum of human herpesvirus 6A (HHV-6A)- and HHV-6B-associated diseases, we sought to develop an HHV-6 species-specific serological assay based on immunoblot analysis. In clinical isolates obtained from patients with exanthem subitum caused by primary HHV-6B infection, PCR products with HHV-6B TRS ranging between 400 and 800 bp were amplified. However, no investigation has been performed in China. However, limited information on the immune response against HHV6B has hampered the development of immunotherapy for HHV6B-driven disease. It is known that the virus establishes latency in the cells of the monocyte/macrophage lineage (11, 13). The genomic sequence allows prediction of a total of 119 unique open reading frames (ORFs), 9 of which are present only in HHV-6B. Consistent with this, the U94-encoded protein was immunologically undetectable in HHV-6B-infected cells.
[Human herpes virus 6 infection in renal transplant recipient--case report]. - PubMed

Whereas astrocytes acutely infected with HHV-6 demonstrated increased glutamate uptake, cells persistently infected with HHV-6A and HHV-6B demonstrated impaired glutamate uptake. HHV-6A was the sole pathogen, the DNA of which was retrospectively detected in patient’s serum. This may not be the complete list of references from this article. Moreover, the virus can be reactivated in patients with drug-induced hypersensitivity syndrome (DIHS), which is a severe form of drug allergy that is characterized by fever, skin rash, lymphadenopathy, hepatitis, and leukocytosis (14,–16). cytomegalovirus (CMV)) or other pathogens were detected in the blood, urine, and stool. Analyses of the U83B-NT activated population identified migrated CCR2+, but not CCR5+, leukocytes. Gradual improvement in clinical status of the patient was observed.

Initial testing on the ocular fluids was normal including gram stain and bacterial culture, fungal smear and culture, and polymerase chain reaction (PCR) for CMV, varicella zoster virus (VZV), herpes simplex virus (HSV), Epstein-Barr virus (EBV), and toxoplasma. Ad esempio, in pazienti sottoposti a trapianto di cellule staminali ematopoietiche, la riattivazione di HHV-6 è stata associata con la riattivazione di CMV e un aumentato rischio di grave malattia da CMV.

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