We analyzed lymphocytes of patients with chronic fatigue syndrome (CFS) for the presence of human herpesvirus 6 (HHV-6) and HHV-7 DNA. Any of the herpes family viruses might be dormant for a long time. The following viruses have been reported as etiologic agents of this disease. While some studies have found that people with chronic fatigue syndrome symptoms tend to have higher blood levels of certain markers, such as blood markers for inflammation, oxidative stress, or previous infections, none of these markers are unique to CFS or can be used to diagnose it. Different tyrosine kinase inhibitors target different proteins though and I’m not sure that imatinib and genostein target the same one exactly though there does seem to be some overlap in the epidermal growth factor receptors and it definitely decreased Nf-kb. 1994;121:953–9…. The sequence of the other PCR product did not correspond with CMV or any other virus.
Viruses that have been associated with CFS/ME and FMS are Human Herpes Virus-6 (HHV-6) and Cytomeglovirus (CMV). Unlike other types of human herpesvirus, HHV-6 can also be inherited from parent to child––A condition often referred to as “chromosomally integrated HHV-6 (CIHHV-6)”––by integrating its DNA into human chromosome. DNA levels of HSV-1 decreased at low-stress but increased at high-stress. Medveczky, the principal investigator of the study, reports that the prevalence of CIHHV-6 in CFS patients with serious neurological symptoms is over twice the level found in the general public. The HHV-6 was also found to be actively replicating in untreated CFS patients with CIHHV-6. This HHV-6 activity was determined by the presence of its messenger RNA (mRNA) – a molecule in the cell that carries and sends protein-building messages. According to Medveczky, patients with CFS-like conditions can benefit from the application of this research.
When CFS patients attempt to exercise at levels that would have been easily tolerated prior to the onset of illness, prolonged, generalized worsening fatigue regularly follows. Reeves, who heads chronic fatigue syndrome research at the Centers for Disease Control and Prevention, cautioned against racing to conclusions based on the findings, even though he characterized them as promising.