Human Herpesvirus 8 Seropositivity Among Sexually Active Adults in Uganda

Human Herpesvirus 8 Seropositivity Among Sexually Active Adults in Uganda

Human Herpesvirus 8 Seropositivity Among Sexually Active Adults in Uganda
Human herpesvirus 8 (HHV-8) infection is common in Africa, but prevalence varies geographically. To address whether immunocompetent individuals control virus reactivation globally or independently and to identify patterns of sporadic reactivation, we monitored herpesviruses and polyomaviruses in 30 adults, over 14 months. It is unclear whether this pattern is driven by greater percentages in stable relationships, and to what extent adults who initiate new relationships may be at risk of incident HSV-2 infection. CD4+ T-cell clones generated from HHV-6-stimulated PBMC were found to proliferate upon stimulation with HHV-6 in the presence of autologous antigen-presenting cells, but not in response to herpes simplex virus type 1 antigen or mock-infected control antigen. Anti-HHV8 antibodies were measured using two enzyme immunoassays targeting synthetic peptides from the K8.1 and orf65 viral genes. However, HSV-1 and HSV-2 accounted for similar proportion of patients with HSV encephalitis (13/25, 52.0% vs. In the new study, Katan’s team used blood samples from 1,625 older adults — average age 69 — to look for indicators of chronic infection with a few common pathogens: HSV and another virus in the herpes family called cytomegalovirus, which usually causes no symptoms; C.

The weighted prevalence of HHV8 seropositivity was 56.2%, based on 1302 seropositive individuals, and it increased significantly with age (Ptrend0.7, when the K8.1 value was 0.5–0.7 and the orf65 was >2.5; samples with K8.1 value 0.5–0.7 and orf65 ≤2.5 were categorized as indeterminate. Samples that did not meet these criteria were categorized as negative.

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