A large body of evidence exists that implicates a number of microbial agents in the pathogenesis of coronary heart disease (CHD). The raised, white, plaque-like lesions, which occurred on about 5% of the fish, healed spontaneously and caused no mortality. Fecal samples were examined for evidence of ascarid or coccidial infection by fecal flotation, and blood smears were examined for hemoparasites. Active CMV infection was diagnosed in 27.8%, active EBV infection in 56.6%, combination of CMV and EBV infection in 46.9% of cases. Regarding the safety endpoints, SAEs (including any complicated varicella cases if observed) will be assessed for all subjects during the whole Phase A duration, whereas, solicited (local and general) and unsolicited adverse events will be assessed in a subset of subjects within a 43-day period after vaccination. Our findings were consistent with those of others who have demonstrated that the HCMV IE1 gene product can block p53 transcriptional activity and induce a dominant negative p53 family member protein [42, 43]. Phosphorylated forms of PERK and eIF2α were specifically detected in HCMV-infected NSPC/iPSCs (Figure 4E and 4F), but not in mock-infected NSPC/iPSCs (Figure 4G).
Their prior serum specimens are analyzed for Chlamydia pneumoniae-specific IgG, IgM antibody, for cytomegalovirus-specific IgG antibody, and for C-reactive protein (CRP).