To the authors’ knowledge, the role of the alphaherpesvirus EHV-1 in equine keratoconjunctivitis has not been speciﬁcally investigated; however, the asso- ciation between the gammaherpesvirus EHV-2 and kera- toconjunctivitis in horses has been studied. Ganciclovir has been reported to inhibit cytomegalovirus, herpes simplex virus types 1 and 2, varicella zoster virus, and Epstein–Barr virus. Procedures: Conjunctival swabs, corneal scrapings, and conjunctival biopsies were collected from 18 horses: 12 clinical cases with idiopathic keratoconjunctivitis and six euthanized controls. 1 We present a novel case of a newborn girl who developed HSV-2 keratoconjunctivitis despite being delivered via an elective, uncomplicated, repeat cesarean over intact chorioamniotic membranes in the absence of active clinical maternal HSV infection and despite having a negative medical history of previous orolabial or genital herpetic infection. Retrobulbar steroid or placebo therapy was begun in matched animals after clinical signs of posterior chorioretinitis appeared. The disease is contagious and can appear as outbreaks in the reindeer herds, affecting calves and young animals in particular. During severe outbreaks, tens of animals can be involved and the most severe symptoms of the disease can appear, leading to permanent blindness.
Impaired vision in addition to discomfort results in decreased feeding; productivity losses during the illness have been estimated up to a 10%-20% loss in body weight in feeder calves. CONCLUSIONS: With clinical specimens the multiplex PCR was as sensitive as its respective uniplex PCRs but more sensitive than adenovirus isolation and as sensitive as herpes simplex virus isolation or C. We have previously concluded that alphaherpesvirus of reindeer, cervid herpesvirus 2 (CvHV2) can initiate such outbreaks and represents the transmissible component of the disease, whereas secondary bacterial infections may contribute to the pathology and destruction of the eyes. Through this project, we want to address the infection biology and pathogenicity of IKC in reindeer, with a particular focus on the role of CvHV2 as the causative agent. This can be a very painful and devastating disease of economic importance for reindeer herders. Further, we want to address possible anti-viral treatment, to see if it is possible to abort CvHV2-infection and the associated pathogenicity, both in cell culture and experimental animals. Intracellular metabolism of acyclic nucleoside analogues and acyclic nucleotide analogues.
PhD student Javier Sánchez Romano (UiT) is associated to the project, with co-supervisors Karen K. Sørensen, Anett K. Larsen and Ingebjørg H. Three days later, he saw a doctor and antiviral treatment was given.