Involvement of cyclooxygenase-2 and EP3 prostaglandin receptor in acute herpetic but not postherpetic pain in mice. – PubMed

Involvement of cyclooxygenase-2 and EP3 prostaglandin receptor in acute herpetic but not postherpetic pain in mice. - PubMed

Involvement of cyclooxygenase-2 and EP3 prostaglandin receptor in acute herpetic but not postherpetic pain in mice. - PubMed
The study, published in the Journal of Translational Medicine, documents the presence of autoantibodies against several cytokines and other autoantigens in patients with herpes zoster (HZ) who have or don’t have PHN. It is essential for viral penetration and for cell to cell spread of virus in vitro, and is also important for neuroinvasiveness. PHN pain is neurogenic, resulting from peripheral nerve injury, and tends to occur in the same site as the shingles. Typically, the pain presents in the distribution of a dermatome over the affected (the nerve distribution) area. Pain resolved up to 2.6 times faster in the two groups receiving famciclovir as compared to those taking placebo. 155:1605–1609, 1995; Choo PW, Galil K, Donahue JG, et al. HSV-1 tends to infect the orofacial areas more often, whereas HSV-2 tends to infect the anogenital regions more often, although either one can affect either site.

Hyperesthesias, allodynia, and burning pain persisted despite nonsteroidal antiinflammatory agents, codeine and hydrocodone. COX-2 mRNA expression and PGE2 content in the affected dorsal root ganglia at the stage of delayed postherpetic pain were similar to those of naive mice. Briefly, mice were acclimated to the instrument, and then their plantar skin was pressed by a von Frey filament having a bending force of 1.6 mN (ca. The results suggest the important roles of COX-2 induction and the PGE2-EP3 receptor system in the dorsal root ganglia in the development but not maintenance of acute herpetic pain. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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