A: I get asked this question a lot. Chickenpox can cause problems for pregnant women, newborns, teens and adults, and people who have immune system problems that make it hard for the body to fight infection. HZ patients (n = 140) had significantly higher IFN-γ ELISPOT responses to VZV antigen than did HC (n = 140). Peters, Patrick H. The mean pain score (95% CI) across age groups at 1 week postrash (n = 106) was 6.0 (5.5, 6.5) and at 2 weeks postrash (n = 119) was 3.5 (2.9, 4.0). The percentage of HZ patients with substantial pain (score ≥ 3) at 6 weeks postrash increased with age from 8% for patients 21 to 49 years of age to 16% for patients 50 to 59 years of age to 22% for patients ≥ 60 years of age. Conclusions These findings support further investigation of ZV administration in early versus later age and of booster doses for elderly individuals at an appropriate interval after initial immunization against HZ.
IFN-γ and IL-2 results for subjects ≥70 years old were significantly higher at baseline and after vaccination in the booster-dose group, compared with the first-dose group, indicating that a residual effect of ZV on VZV-specific CMI persisted for ≥10 years and was enhanced by the booster dose. In PIENTER 1 a VZV IgGELISA kit (Human, Wiesbaden, Germany) was used. Varicella-zoster virus (VZV) antibody titers by glycoprotein enzyme-linked immunosorbent assay (gpELISA) were measured at baseline and at Week 6 postvaccination. No subjects reported a VZV-like rash. Ideally, to avoid additional stress, have the cat given whatever vaccinations are called for at a later date by a home-visiting veterinarian. A single dose of zoster vaccine induced VZV-specific gpELISA antibody response and was generally well-tolerated in healthy Korean adults ≥50 yr of age (registry at www.clinicaltrial.gov No. Postpartum pertussis immunization does not prevent infection in young infants Castagnini et al.