New acridone inhibitors of human herpes virus replication. – PubMed

New acridone inhibitors of human herpes virus replication. - PubMed

New acridone inhibitors of human herpes virus replication. - PubMed
A new sensitive and rapid enzyme-linked immunosorbent assay (ELISA) test (Du Pont HERPCHEK) for the detection of herpes simplex virus (HSV) antigen was evaluated. Plus Christian Niedan reports on Hans Sachs’ collection of poster art reclaimed from the Nazis; Rebecca Honig Friedman looks at art by unrecognized Abstract Expressionist painter Ruth Abrams; and Steven I. The reservoir of this virus in nature is not known but it is not likely to be the marmoset. The trifluoroethanesulfonyl substrate 9 appears to be the better labeling precursor. The levels of expression of wild-type HSV1-tk and HSV1-A167Ytk, HSV1-sr39tk, and HSV1-A167Ysr39tk mutants fused with green fluorescent protein (GFP) and transduced into U87 cells were normalized to the mean fluorescence of GFP measured by fluorescence-activated cell sorting. ARE are frequently found in mRNA that encode proto-oncogenes, nuclear transcription factors, and cytokines. Inhibition of HSV replication by these agents is best understood and it occurs after viral DNA synthesis.

The mechanism for one prototype inhibitor (5-chloro-1,3-dihydroxy acridone), involves a blockade of viral DNA maturation (cleavage/packaging) and viral capsids accumulate abnormally. The new resource provides a series of information leaflets, which are endorsed by professional body the International Herpes Management Forum (IHMF) (3). At this time it is unclear whether atypical target-interaction or unusual polypharmacology is responsible for the antiviral activities observed and this key issue will hamper future drug development until it is resolved.

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