NIST Standard Available for Better Diagnosis, Treatment of Cytomegalovirus

NIST Standard Available for Better Diagnosis, Treatment of Cytomegalovirus

Vaginal pro-inflammatory cytokine expression during herpes virus reactivation was examined in HIV-infected women before and after initiation of ART. We treated 16 patients with AdV hemorrhagic cystitis (HC) following HSCT with cidofovir (CDV; 1 mg/kg/day, three times weekly for 3 weeks). Cytomegalovirus, which is transmitted by sexual contact or exposure to infected body fluids, is not highly contagious and rarely causes serious illness in otherwise healthy adults, occasionally producing mononucleosis-like symptoms. CMV retinitis is a sight-threatening viral infection that progresses rapidly and may lead to blindness. The evidence we found shows that some antiviral drugs (ganciclovir, valaciclovir and aciclovir) reduced the risk of CMV disease, death due to CMV disease, clinical disease caused by herpes simplex and herpes zoster viruses, bacterial infections and protozoal infections. In animals treated daily with HDP-CDV or ODE-CDV, virus titers in lung, liver, spleen, kidney, pancreas, salivary gland, and blood were reduced 3 to 5 log10-fold, which was comparable to CDV given intraperitoneally. Results:: As expected, untreated HCMV-infected ARPE-19 cells showed decreased NF-ΚB expression, but, in contrast, untreated HSV-1-infected ARPE-19 cells showed increased NF-ΚB expression.
NIST Standard Available for Better Diagnosis, Treatment of Cytomegalovirus

Twenty-three (51.1%) displayed cytomeg virus (CMV) infections and 12 (26.7%) HHV-6 infection. They can also be given to suppress recurrent genital herpes. Ninety-three patients were evaluable for CMV infection. SRM 2366 consists of three solutions, each with a specific concentration of CMV DNA copies per microliter: 420, 1,702 and 19,641. These are designed to qualify prepared calibration samples (known as calibrants). They also can be used as quality control samples for diagnostic equipment. For added traceability, the SRM certificate of analysis includes the genetic sequences of the nine CMV genome regions copied for the standard.

FDA clearance followed a unanimous recommendation from an advisory committee on March 15 and was based upon data from two pivotal studies demonstrating that VISTIDE delays the time to progression of CMV retinitis. Standard Reference Materials are among the most widely distributed and used products from NIST. In addition, the analogs retained their activity against drug-resistant isolates with mutations in the UL97 or UL54 gene.

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