Patent 2182888 Summary – Canadian Patents Database

Patent 2182888 Summary - Canadian Patents Database

Canine herpes virus is found throughout the world in domestic and wild dogs. The disease is always present in the environment for your dog to pick up. The infection may flare up and become a clinical problem during periods of stress or immunosuppression. This is because adding leptospirosis ingredients to combination vaccines can reduce the protection effectiveness of the other ingredients. In this study, we explored the potential of using canine tumor cells as carriers for delivery of oncolytic canine adenovirus to tumor sites in a xenograft animal model. The vector of claim 12 wherein at least one additional virus-encoded open reading frame is deleted; and, the additional virus-encoded open reading frame is selected from the group consisting of: J2R, B13R + B14R, A26L, A56R, and I4L. The virus can cross the placenta and infect them while they are still within the uterus, or they may become exposed from vaginal secretions during birth.

I’d like to use this experience to educate those of you who have no idea that this awful virus exists. Up to 90 percent of all cats can be infected with herpes FHV-1, and many are infected at birth from their mothers. The virus can also become airborne from nasal secretions of the mother, so once born, the pup can actually inhale the virus while breathing. 16. FHV-1 is species-specific and will not transmit to humans or other pets. 19. This can be another dog that was recently infected at a dog show or kennel or a carrier dog that relapsed due to a stressful situation.

Patent 2182888 Summary - Canadian Patents Database
Their feces are soft and yellow-green. The vector of claim 20 wherein the canarypox virus is a Rentschler vaccine strain which was attenuated through more than 200 serial passages on chick embryo fibroblasts, a master seed therefrom was subjected to four successive plaque purifications under agar, from which a plaque clone was amplified through five additional passages. Bitches without antibodies at the time of pregnancy that get exposed to virus may  resorb if the infection occurs during the first 28 days of pregnancy. Then pets wading, swimming or drinking the contaminated water, develop the disease. PCR (polymerase chain reaction).. pomona, L. All viruses were purified using a double CsCl gradient.

The vector of claim 39 wherein at least one additional virus-encoded open reading frame is deleted; and, the additional virus-encoded open reading frame is selected from the group consisting of: J2R, B13R + B14R, A26L, A56R, and I4L. Those that live often develop into carrier adults just like their parents.It appears that the virus thrives best at a temperature of around 99ºF, so this may help to explain why older puppies are at less risk since their body temperature is usually around 101.5ºF, and that of younger puppies is lower.Adult carriers typically exhibit no obvious symptoms, however, small blister-like lesions may occasionally be noted on the vaginal wall. Back at home, someone was watching over Beretta and her remaining two puppies when one of them, Andy, started screaming too. After an outbreak, your cat’s eye might water frequently, and there is no cure or preventative. Those that live often develop into carrier adults just like their parents.It appears that the virus thrives best at a temperature of around 99?F, so this may help to explain why older puppies are at less risk since their body temperature is usually around 101.5?F, and that of younger puppies is lower.Adult carriers typically exhibit no obvious symptoms, however, small blister-like lesions may occasionally be noted on the vaginal wall. 43. Adult cats rarely die from herpes FHV-1, and usually only from complications that follow lack of treatment.

46. When a puppy under 3-4 weeks of age becomes infected with this virus, the disease takes an entirely different course than it does in an older dog. Autopsies of decreased puppies by a veterinary pathologist can reveal the characteristic herpes lesions. The vector of claim 47 wherein the canarypox virus is a Rentschler vaccine strain which was attenuated through more than 200 serial passages on chick embryo fibroblasts, a master seed therefrom was subjected to four successive plaque purifications under agar, from which a plaque clone was amplified through five additional passages. In the former group the deadly systemic form of the disease is more likely, whereas in the latter group, the likelihood of the respiratory form is greater. These are the pets most likely to suffer life-threatening liver and kidney damage. 67.

In these animals, the leptospira have taken up residence in their kidneys. 68. The vector of claim 66 wherein at least one additional virus-encoded open reading frame is deleted; and, the additional virus-encoded open reading frame is selected from the group consisting of: a thymidine kinase gene, a hemorrhagic region, an A type inclusion body region, a hemagglutinin gene, and a large subunit, ribonucleotide reductase. 73. The vector of claim 59 which is a modified recombinant avipox virus which is modified so that it has attenuated virulence in a host; and, which contains the isolated nucleic acid of claim 58 in a nonessential region of the virus genome.

You may also like