Seroepidemiology and molecular epidemiology of Kaposi’s sarcoma-associated herpesvirus among Jewish population groups in Israel. – PubMed

Seroepidemiology and molecular epidemiology of Kaposi's sarcoma-associated herpesvirus among Jewish population groups in Israel. - PubMed

Seroepidemiology and molecular epidemiology of Kaposi's sarcoma-associated herpesvirus among Jewish population groups in Israel. - PubMed
To clarify the occurrence of the caprine herpesvirus (BHV-6) infection in the goat population in the GDR, 175 sera, collected from the agricultural research station of Karl-Marx-Universität at Probstheida were tested for the presence of neutralizing antibodies against BHV-6. The risk factors for KSHV infection have been extensively studied for Western countries but remain largely undefined for other parts of the world. A prevailing view is that childhood transmission is primarily responsible for the high seroprevalence of KSHV among adults that is observed throughout the continent. The sequences of conserved ORF22 and K6 genes were typical of HHV-8, but the variable K1 gene sequences were only 70%-75% identical to other known HHV-8 strains. Women had a personal interview and gynecologic examinations in which a blood sample, cervical cells and oral cells were obtained. To analyze the effects of various factors on the risk of KSHV infection for both the HBV-positive cohort and their families, logistic regression for cluster data and generalized estimating equations were used. All statistical tests were two-sided.

Stanley. Weiss, C. The most important risk factors found for both husband and wife to test KSHV positive were their own places of birth and their spouse’s seropositivity. For a child to test positive, the most important risk factor was maternal seropositivity. The crude prevalence rate of KSHV among the Jewish population in Israel is 9.9%. Financial support: National Institutes of Health (K01 HD052020, T32 MH19105, U01 AI052142, R01 CA119903, and HHSN261200800001E), Gladstone Institute of Virology and Immunology-University of California, San Francisco Center for AIDS Research (P30 AI027763), AIDS Malignancy Consortium (U01 CA078124), University of California Universitywide AIDS Research Program (CC99-SF-001), South Africa National Research Foundation (Thuthuka Programme Grant 2054349), Doris Duke Charitable Foundation (to P.J.R. The presence of KSHV in Jews in Israel of all ethnic origins and their high incidence of reported Kaposi’s sarcoma suggest that KSHV was introduced into the Jewish population prior to the major Diaspora.

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