Genital herpes is an important public health disease and is the leading cause of genital ulcer disease worldwide. Local drug delivery may provide a more targeted and efficient option than systemic delivery for diseases of the oral mucosa. Lesions in men were larger and lasted longer but were less symptomatic than those in women. Phytomedicine : international journal of phytotherapy and phytopharmacology. Syed TA, Cheema KM, Ashfaq A, et al. Adults with physician-confirmed herpes labialis were recruited to apply to the trial. Genital herpes is caused by infection with herpes simplex virus (HSV), commonly by HSV type 2 and now increasingly by type 1.
Participants were instructed to complete online questionnaires at 2-week intervals and, at the initiation of a cold sore, daily “outbreak questionnaires” until outbreak termination. Feasibility outcome measures included trial participant characteristics, frequency of cold sores, participant retention and adherence (to study medication), and data completeness. Encephalitis in immunocompetent patients due to herpes simplex virus type 1 or 2 as determined by type-specific polymerase chain reaction and antibody assays of cerebrospinal fluid. It is neither intended nor implied to be a substitute for professional medical advice. 16 were randomized into the verum group and 16 into the placebo group. Most people with HSV infection have mild unrecognised or subclinical disease and are unaware of their infection. During the trial, 34 outbreaks were reported among 23 (72%) participants, resulting in a cold sore incidence rate of 19.8 per 100 person-months of observation.
Online data were available for 32 outbreaks; the absence of a resolution date made it impossible to accurately calculate the duration of 12 (38%) outbreaks. . The DSS group has statistically significant lower mean pain scores (3.1 vs 7.6, P =.04), but participants in this group also consumed more acetaminophen tablets than the placebo group (1.1 versus 0.5, P=.55). Adherence to medication was similar in both groups: 7 (50%) of the verum group reported using the cream as directed compared to 6 (46.2%) in the placebo group; (P =.8). Take swabs from the base of the lesion or fluid from a vesicle. However, participant adherence to the daily outbreak visit schedules was low and only 7 (50%) participants used the cream as directed. These limitations could be addressed in future Internet-based studies by using Personal Digital Assistants (PDAs), using reminder devices, and providing incentives.
Chen JY, Chang CY et al.