Shingles Research outline

Shingles Research outline

Shingle ophthalmicus caused by Varicella zoster can occur by two mechanisms. Herpes zoster ophthalmicus in patients at risk for the acquired immune deficiency syndrome (AIDS). It is a devastating condition with blisters and a crusty rash. We present a patient with herpes zoster ophthalmicus who presented with face and neck pain associated with visual symptoms mimicking carotid artery dissection. Electron microscopy of the retinal lesions disclosed round to oval enveloped viral particles that were characteristic of the herpesviruses. It is not clear why this happens. Keratoconjunctivitis can occur within a few days of dermal involvement.

Besides pain and rash in the affected ophthalmic dermatome other acute stage ocular involvement includes swelling and reddening of eye, ptosis with some even developing blepharitis and vesicular lesions which mostly resolves with scarring. These blisters will then rupture and quickly crust over. A person’s risk for herpes zoster increases sharply after 50 years of age. About 50% of people who live to 85 years of age will have had an episode of herpes zoster. A person’s risk for PHN also increases sharply with age. Post-therapeutic neuralgia is more common in patients older than 60 years of age, with 50% experiencing severe pain for more than 12 months. Finally, one study indicated that dietary micronutrient intake was protective against zoster.

The testing and diagnosing is a simple process based mainly on the rash and pain involved. At first you may have a headache or be sensitive to light. You may also     feel like you have the flu but not have a fever. Later, you may feel itching, tingling, or pain in a certain area. Pseudodendites affect the epithelium and are elevated, branching lesions that differ from dendritic lesions of herpes simplex. A prospective cohort study indicated a nonsignificant association (p = 0.078) between zoster risk and negative life events. However, there are some people who develop chronic disease like uveitis and they will require long term therapy maybe for years.
Shingles Research outline

It takes 2 to 4  weeks for the blisters to heal, and they may leave scars. Some people only get     a mild rash, and some do not get a rash at all. It’s possible that you could also feel dizzy or weak, or you could have long-term pain or a rash  on your face, changes in your vision, changes in how well you can think, or a rash that spreads. Neurotrophic keratitis has been reported in 10 to 25% of patients suffeing Herpes zoster ophthalmicus. Permanent sequelae of ophthalmic zoster infection may include chronic ocular inflammation, loss of vision, and debilitating pain. The people who should not receive this vaccine are the ones who have experienced any form of life-threatening or allergic reaction to the use of gelatin, as well as the anti-biotic neomycin, and any other shingles vaccine component. Blood tests may show an increase in white blood cells and antibodies to the chickenpox virus, but they cannot confirm that the rash is due to shingles.

Your healthcare provider may prescribe a medicine that fights the virus, called an antiviral drug. This drug helps reduce pain, prevent complications, and shorten the course of the disease. Other cranial nerves in communication with the trigeminal nerve, such as the VII, VIII, IX, or X nerves and cervical nerves II to IV, may also be involved. Thus, when ophthalmic zoster affects the side and the tip of the nose, careful attention must be given to the condition of the eye and immediate ophthalmologic consultation is necessary in order to prevent complications of the eye and central nerve system Zoster Infection. It is best to start taking them before the blisters appear. The drugs are usually given in pill form, and in high doses. Some people may need to receive the medicine through a vein (by IV).

Strong anti-inflammatory medicines called corticosteroids, such as prednisone, may be used to reduce swelling and pain. These drugs do not work in all patients. Normal aging, poor nutrition, and immunocompromised status correlate with outbreaks of herpes zoster, and certain factors such as physical or emotional stress and fatigue may precipitate an episode.Herpes zoster ophthalmicus occurs when reactivation of the latent virus in the trigeminal ganglia involves the ophthalmic division of the nerve. If the virus affects the nerves that control movement (the motor nerves), you may have temporary or permanent weakness or paralysis. Sometimes, the pain in the area where the shingles occurred may last from months to years. This pain is called postherpetic neuralgia. Postherpetic neuralgia is more likely to occur in people over age 60.

It occurs when the nerves have been damaged after an outbreak of shingles. Both conditions may be accompanied by localized stromal keratitis.ACUTE RETINAL NECROSIS AND PROGRESSIVE OUTER RETINAL NECROSIS SYNDROMESHerpes zoster virus is considered the offending agent in most cases of acute retinal necrosis and progressive outer retinal necrosis syndromes. In order to compose the paper I wrote about Shingles, I did and outline to structure the information for the paper, and what order it best made sense in. After I made this here outline, I removed the bullet points, added a few more sentences to form transitions, and made the finished product, my Shingles paper.

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