Successful therapy of herpes hominis keratitis in rabbits by 5-iodo-5′-amino-2’5′-dideoxyuridine (AIU): a novel analog of thymidine. – PubMed

Successful therapy of herpes hominis keratitis in rabbits by 5-iodo-5'-amino-2'5'-dideoxyuridine (AIU): a novel analog of thymidine. - PubMed

We mapped sympathetic renal preganglionic neurons in the rabbit spinal cord using Herpes simplex virus retrograde transneuronal tracing after application of the virus to the renal nerve. In these animals EEG tracings showed the development of seizure discharges occurring on a background of irregular slow waves. Double-labelling immunohistochemical studies were performed to determine the relationship of neuropeptide Y-immunoreactive axons to virus-labelled perikarya and dendrites. However, no studies have been published concerning influences of HSV on the neurotransmitters in the raphe. During the active stage of the disease, herpes virus replication within cells causes development of tissue lesions in the affected area. At this point, a few basal epithelial cells were incorporating tritium-labeled thymidine. per milliter; and (5) AIU, 8 mg.
Successful therapy of herpes hominis keratitis in rabbits by 5-iodo-5'-amino-2'5'-dideoxyuridine (AIU): a novel analog of thymidine. - PubMed

The agent was classified as HSV-1 by polymerase chain reaction analysis. Each eye was examined daily for 12 days and graded independently by two ophthalmologists. Although IdUrd and AIU (8 mg. per milliliter) were effective therapeutically, IdUrd had a greater effect. The AIU at 1 and 4 mg. per milliliter were less active, but showed more rapid healing than the saline control. 68:1283-1292, 1994; J.

These virus particles are transported retrogradely to cell bodies in TG, where the virus establishes a lifelong latent infection (17). Although less potent than IdUrd, AIU does provide effective therapy for herpes keratitis.

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