The consequences of antiviral therapy on herpesvirus shedding

The consequences of antiviral therapy on herpesvirus shedding

The consequences of antiviral therapy on herpesvirus shedding
DALLAS, July 11 — Treatment with one month of an antiviral drug before birth significantly reduces the need for a Cesarean among women with chronic genital herpes, found investigators here. The approval is limited to otherwise healthy adults with competent immune systems, and suppressive therapy should be used in combination with “safer sex practices,” the FDA said in a statement. Australian Family Physician, Vol. The valaciclovir transmission study provides evidence that an antiviral agent can interrupt the transmission of a viral sexually transmitted disease between serologically discordant sexual partners. In a randomized, placebo-controlled trial, the antiviral Valtrex (valacyclovir) reduced the rate of clinical herpes simplex virus (HSV) at delivery by 70%, according to Jeanne Sheffield, M.D., of the University of Texas Southwestern Medical Center. Correct diagnosis is essential for appropriate management and reduction of transmission. There is no cure for herpes, so the goals of treatment are to reduce the number of outbreaks and to lessen symptoms when you do have an outbreak.

Acyclovir, Valacyclovir and famcyclovir can lessen the severity of a primary outbreak, reduce the time it takes genital herpes outbreaks to heal and can decrease the number of days of symptoms and days the virus is transmissible. Acyclovir is used to decrease pain and speed the healing of sores or blisters in people who have varicella (chickenpox) ) , herpes zoster (shingles; a rash that can occur in people who have had chickenpox in the past) , and first-time or repeat outbreaks of genital herpes (a herpes virus infection that causes sores to form around the genitals and rectum from time to time). The group analyzed genital swabs that were collected twice daily for 30 days and employed quantitative PCR for viral DNA detection, which is indicative of viral shedding. Routine labs were sent off as part of her physical exam and a viral and bacterial culture of the labia were sent of as well. Drug treatment also decreased the frequency, expansion rate, duration, and re-expansion likelihood of shedding episodes. The odds ratio was 0.18, with a 95% confidence interval from 0.04 to 0.82; P=0.02. These other options are the use of male condoms, and awareness of subtle signs and symptoms of genital herpes and abstaining from intercourse when these symptoms are present.

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