There are at least two hurdles confronting the use of the adenovirus (Ad)-mediated herpes simplex virus thymidine kinase (HSVtk)/ganciclovir (GCV) system for the treatment of cancer. Gamma herpes viruses are different from the herpes simplex viruses responsible for cold sores and genital herpes. TCM and Western medicine can work hand-in-hand by integrating both therapies and creating synergies. At his cancer center at 4875 Higbee Ave. Increasing numbers of recent studies have revealed parallels between bacteria and cancer (eg, rapid proliferation, rapid development of drug resistance, and high phenotypic variability).4 It has been conjectured that cancer shares so many features in common with bacteria because it represents an atavistic form of life, which ensued following a breakdown of regulatory pathways that evolved upon the transition from prokaryotes to eukaryotes.5 This breakdown unlocked “ancient toolkits,” and thus cancer cells resort to more fundamental strategies that have been developed by bacteria through the course of evolution. As the infected cancer cells are destroyed by lysis, they release new infectious virus particles to help destroy the remaining tumor. Dr.
Earlier this year, research findings presented at the annual meeting of the European Society for Medical Oncology in Switzerland showed promising results using modified herpes simplex virus to target liver and colorectal cancer cells. That effect lasted at least six months. Because of this, the FDA says the treatment should not be offered to pregnant women or patients with suppressed immune systems. The version used in the treatment was genetically engineered to produce the molecule GM-CSF, which drives the immune system to destroy tumors. Particular focus will be given to strategies for arming oncolytic viruses with therapeutic genes capable of eliciting antitumor immune function, inhibition of tumor neovascularization, or prodrug activation.