The process dynamics of viral and bacterial diseases of the central nervous system. – PubMed

The process dynamics of viral and bacterial diseases of the central nervous system. - PubMed

The process dynamics of viral and bacterial diseases of the central nervous system. - PubMed
Central nervous system (CNS) infections can have various presentations including Cerebrovascular accidents (CVA) which may go unrecognized as a presentation of infection. The case is also of interest because it mimicked herpes encephalitis both clinically and radiologically. —A well preserved woman, aged 72, developed typical and extensive herpes zoster over the right cervical region, extending from the hairline almost to the clavicle. In the descriptions of epidemic influenza written before 1889 the respiratory symptoms were made most prominent. Definite diagnosis of NMO is based on evidence of optic neuritis, acute myelitis, and at least 2 of the following additional criteria: (a) contiguous spinal cord MRI lesions over 3 vertebral segments, (b) brain MRI not meeting criteria for MS, and (c) presence of antibodies against aquaporin-4, a highly specific marker of NMO (61). This confinement of the imm une privilege to the parenchyma has also been demonstrated for experimental influenza virus infection in which confinement of the infection to the brain parenchyma did not result in efficient immune system priming whereas infection of the CSF elicited a virus-specific immune response comparable to that of intranasal infection (Stevenson et al. Finally, CNS-infiltrating mononuclear cells from IL-4-treated mice produced lower levels of MCP-1 mRNA compared with control mice.

Importantly, it also provides a route for therapy, particularly as gene delivery of cytokines can be shown to be more efficacious than bolus protein delivery. Mortality rate among non-infectious complications was 12/53 (22.6%).

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