Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failure. – PubMed

Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failure. - PubMed

Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failure. - PubMed
Frequency of active human herpesvirus-6, -7 (HHV-6, HHV-7) and parvovirus B19 (B19) infection/coinfection and its association with clinical course of ME/CFS was evaluated. Here we present a pediatric case of DRESS complicated by human herpesvirus (HHV)-6 reactivation. La gravité est liée à la survenue d’atteintes viscérales (hépatite, hémophagocytose, encéphalite, pneumopathie, insuffisance rénale, pancréatite, thyroïdite…) qui peuvent évoluer vers un tableau de défaillance multiviscérale et conduire à un transfert en réanimation. In this study, we investigated the presence of HHV-6 in the gastroduodenal mucosa of liver transplant recipients and in immunocompetent patients undergoing gastroscopic examination because of dyspeptic symptoms. Gerardo. Viral infections, especially those caused by herpesviruses such as cytomegalovirus (CMV), represent a major cause of morbidity, particularly after allogeneic transplantation, but they can also affect autologous recipients. At the time of the first endoscopic investigation, most patients received antiviral prophylaxis with aciclovir.

We identified a number of allogeneic HCT recipients with HHV-6 DNA in CSF who did not meet criteria for HHV-6 CNS dysfunction. Acquisition time was defined as the halfway point between the last negative and first positive saliva test. Some specificities of visceral involvement were associated with allopurinol and minocycline. However, visceral involvement comprising multiorgan failure seemed to be unpredictable. Better knowledge of DRESS is necessary to propose specific and prompt treatment. Early demonstration of human herpesvirus 6 reactivation could be considered a prognostic factor for identifying patients at higher risk and, hence, needs to be evaluated.

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