Type specificity of complement-requiring and immunoglobulin M neutralizing antibody in initial herpes simplex virus infections of humans.

Type specificity of complement-requiring and immunoglobulin M neutralizing antibody in initial herpes simplex virus infections of humans.

Type specificity of complement-requiring and immunoglobulin M neutralizing antibody in initial herpes simplex virus infections of humans.
Infection with many encephalitic viruses is associated with the induction of the proinflammatory cytokine interleukin (IL)-6. I would wait six weeks and then repeat the tests. In patients with initial HSV type 1 infections, the IgM neutralizing antibody response was type specific. Contributed reagents/materials/analysis tools: KP HF IG. The major immunodominant antigens of Borrelia are conserved across strains from Europe and Asia. The fused partner can be any other proteinaceous molecule of interest, such as a ligand that activates upon interaction with a cell-surface receptor, a peptidic antigen (Ag) against a challenging pathogen or a ‘bait’ protein to identify binding partners assembled in a protein microarray. Protein microarray, a high-throughput and powerful detection tool in medical research, is characterized methodologically as that of gene microarray, including robotic printing of probe targets, hybridization with samples of interest, and detection of interaction by high-resolution scanning and image analysis [1], [2].

Get a printable copy (PDF file) of the complete article (780K), or click on a page image below to browse page by page. Covalent attachment of C3 fragments to virus particles may indicate the infectious origin of the antigen and may lead to enhanced efficiency of B cell responses via co-ligation of the B cell receptor (BCR) and the complement receptor signaling complex CD21/CD19/CD81 on B lymphocytes (Carroll, 2004).

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