Ultraviolet Light Induces Reactivation in a Murine Model of Cutaneous Herpes Simplex Virus-1 Infection

Ultraviolet Light Induces Reactivation in a Murine Model of Cutaneous Herpes Simplex Virus-1 Infection

The illumigene® HSV 1&2 DNA amplification assay, performed on the illumipro-10™, is a qualitative in vitro diagnostic test for the direct detection and differentiation of herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) in cutaneous and mucocutaneous lesion specimens. The kethoxal formulation was not significantly more effective than the placebo. The underlying mechanism of the specific susceptibility to these chronic cutaneous viral infections is currently unknown, largely because the effect of DOCK8 deficiency has not been studied in suitable models. Only liposomes prepared by the dehydration-rehydration method were effective. We have been able to detect viral DNA in small punch skin biopsies with this procedure, which can take as little as 6 h. In addition, peak HSV-IFN-γ titers in mouse trigeminal ganglia (TG) and brain were similar for all viruses, although HSV-IFN-γ appeared in the TG and brains of ocularly infected mice earlier than either parental virus. N.

Fields and D. Knipe), pp. 2297–2341. Raven Press, New York.Nahmias, A. J. and B. Roizman.

1973. Infection with herpes simplex virus 1 and 2.1. N. Engl. J. Med 289:667–674. Nahmias, A.

J. and B. Roizman. 1973. Infection with herpes simplex virus 1 and 2.2. N. Engl.

J. Med 289:719–725. Nahmias, A. J. and B. Roizman. 1973.

Infection with herpes simplex virus 1 and 2.3. N. Engl. J. Med 289:781–789. Roizman, B. and A.

Sears. 1996. Herpes simplex viruses and their replication. In Fields Virology, 3rd Ed. (Edited by B. N. Fields and D.

Knipe), pp. 2231–2295. Raven Press, New York. Hirsch, M. S. 1995. Herpes simplex virus.

In Principles and Practice of Infectious Diseases (Edited by G. L. Mandell, J. E. Bennett and R. Dolan), pp. 1336–1344.

Churchill Livingstone, New York. Koelle, D. M., J. Benedetti, A. Langenberg, and L. Corey. 1992.

Asymptomatic reactivation of herpes simplex virus in women after the first episode of genital herpes. Ann. Intern. Med 116:433–437. Mertz, G. J., R. W.

Coombs, R. Ashley, J. Jourden, M. Remington, C. Winter, A. Fahnlander, M. Guinana, H.

Ducey, and L. Corey. 1988. Transmission of genital herpes in couples with one symptomatic and one asymptomatic partner: a prospective study. J. Infect. Dis 157:1169–1177.

Wald, A., J. Zeh, S. Selke, R. L. Ashley, and L. Corey. 1995.

Virologic characteristics of subclinical and symptomatic genital herpes infections. N. Engl. J. Med 333:770–775. Levin, M. J.

1993. Impact of herpesviruses in the future. J. Med. Virol 1:0158–164. Peterslund, N. A.

1991. Herpesvirus infection: an overview of the clinical manifestations. Scand. J. Infect. Dis 80:015–20. Wagner, E.

K. and D. C. Bloom. 1997. Experimental investigation of herpes simplex virus latency. Clin.

Microbiol. Rev 10:419–443. Rawls, W. E. 1979. Herpes simplex virus types 1 and 2 and herpesvirus simiae. In Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections (Edited by E.

H. Lennette and N. J. Schmidt), pp. 309–360. American Public Health Association, Washington. Beasley, D.

G., J. Beard, J. W. Stanfield, and L. K. Roberts. 1996.

Evaluation of an economical sunlamp that emits a near solar UV power spectrum for conducting photoimmunological and sunscreen immune protection studies. Photochem. Photobiol 64:303–309. Wolf, P., C. K. Donawho, and M. L.

Kripke. 1993. Analysis of the protective effect of different sunscreens on ultraviolet radiation–induced local and systemic suppression of contact hypersensitivity and inflammatory responses in mice. J. Investig. Dermatol 100:254–259. Reeve, V.

E., C. Boehm-Wilcox, M. Bosnic, and W. G. Reilly. 1994. Differential photoimmunoprotection by sunscreen ingredients is unrelated to epidermal cis urocanic acid formation in hairless mice.

J. Investig. Dermatol 103:801–806. Folpe, A., L. W. Lapham, and H. C.

Smith. 1994. Herpes simplex myelitis as a cause of acute necrotizing myelitis syndrome. Neurology 44:1955–1957. Kinjo, T., K. Tsuhako, W. Siriungsi, K.

Sunagawa, I. Nakazato, and T. Iwamasa. 1997. Experimental myelitis caused by herpes simplex virus type 2 in C57BL/6N and BALB/cN mice. Int. J.

Exp. Pathol 78:401–409. Townsend, J. J. and P. K. Collins.

1986. Peripheral nervous system demyelination with herpes simplex virus. J. Neuropathol. Exp. Neurol 45:419–425. Ashley, R.

1993. Laboratory techniques in the diagnosis of herpes simplex infection. Genitourin. Med 69:174–183. Rooney, J. F., S. E.

Straus, M. L. Mannix, C. R. Wohlenberg, S. Banks, S. Jagannath, J.

E. Brauer, and A. L. Notkins. 1992. UV light–induced reactivation of herpes simplex virus type-2 and prevention by acyclovir. J.

Infect. Dis 166:500–506. Spruance, S. L., D. J. Freeman, J. C.

Stewart, M. B. McKeough, L. G. Wenerstrom, G. G. Krueger, M.

W. Piepkorn, W. G. Stroop, and N. H. Rowe. 1991.

The natural history of ultraviolet radiation–induced herpes simplex labialis and response to therapy with peroral and topical formulations of acyclovir. J. Infect. Dis 163:728–734. Perna, J. J., M. L.

Mannix, J. F. Rooney, A. L. Notkins, and S. E. Straus.

1987. Reactivation of latent herpes simplex virus infection by ultraviolet light: a human model. J. Am. Acad. Dermatol 17:473–478. Spruance, S.

L. 1985. Pathogenesis of herpes simplex labialis: experimental induction of lesions with UV light. J. Clin. Microbiol 22:366–368. Blatt, A.

N., K. A. Laycock, R. H. Brady, P. Traynor, D. J.

Ultraviolet Light Induces Reactivation in a Murine Model of Cutaneous Herpes Simplex Virus-1 Infection
Krogstad, and J. S. Pepose. 1993. Prophylactic acyclovir effectively reduces herpes simplex virus type 1 reactivation after exposure of latently infected mice to ultraviolet B. Investig. Ophthalmol.

Vis. Sci 34:3459–3465. Blyth, W. A., T. J. Hill, H. J.

Field, and D. A. Harbour. 1976. Reactivation of herpes simplex virus infection by ultraviolet light and possible involvement of prostaglandins. J. Gen.

Virol 33:547–550. Ecob-Prince, M. and K. Hassan. 1994. Reactivation of latent herpes simplex virus from explanted dorsal root ganglia. J.

Gen. Virol 75:2017–2028. Harbour, D. A., T. J. Hill, and W. A.

Blyth. 1983. Recurrent herpes simplex in the mouse: inflammation in the skin and activation of virus in the ganglia following peripheral stimulation. J. Gen. Virol 64:1491–1498. Junejo, F.

and S. M. Brown. 1995. Latent phenotype analysis of three deletion variants of herpes simplex virus type 1 (HSV-1) in mouse model. J. Pakistan Med.

Assn 45:99–104. Miller, J. K., K. A. Laycock, J. A. Umphress, K.

K. Hook, P. M. Stuart, and J. S. Pepose. 1996.

A comparison of recurrent and primary herpes simplex keratitis in NIH inbred mice. Cornea 15:497–504. Norval, M., S. E M. Howie, J. A. Rossand, and J.

P. Maingay. 1987. A murine model of herpes simplex virus recrudescence. J. Gen. Virol 68:2693–2698.

Podlech, J., F. Hengerer, M. Fleck, K. Eray, and D. Flake. 1996. Asymptomatic vaginal herpes simplex virus infections in mice: virology and pathohistology.

Arch. Virol 141:263–274. Sawtell, N. M. and R. L. Thompson.

1992. Rapid in vivo reactivation of herpes simplex virus in latently infected murine ganglionic neurons after transient hyperthermia. J. Virol 66:2150–2156. PubMed Shimeld, C., T. Hill, B. Blyth, and D.

Easty. 1989. An improved model of recurrent herpetic eye disease in mice. Curr. Eye Res 8:1193–1205. Underwood, G. E.

and S. D. Weed. 1974. Recurrent cutaneous herpes simplex in hairless mice. Infect. Immun 10:471–474.

Willey, D. E., M. D. Trousdale, and A. B. Nesburn. 1984.

Reactivation of murine latent HSV infection by epinephrine iontophoresis. Investig. Ophthalmol. Vis. Sci 25:945–950. Shimeld, C., J. L.

Whiteland, N. A. Williams, D. L. Easty, and T. J. Hill.

1996. Reactivation of herpes simplex virus type 1 in the mouse trigeminal ganglion: an in vivo study of virus antigen and immune cell infiltration. J. Gen. Virol 77:2583–2590. Tenser, R. B., W.

A. Edris, and K. A. Hay. 1993. Neuronal control of herpes simplex virus latency. Virology 195:337–347.

Garssen, J., R. van der Molen, A. de Klerk, M. Norval, and H. van Loveren. 2000. Effects of UV irradiation on skin and nonskin-associated herpes simplex virus infections in rats.

Photochem. Photobiol 72:645–651. BioOne Millhouse, S. and B. Wigdahl. 2000. Molecular circuitry regulating herpes simplex virus type 1 latency in neurons.

J. Neurovirol 6:6–24. Cantin, E., B. Tanamachi, and H. Openshaw. 1999. Role for gamma interferon in control of herpes simplex virus type 1 reactivation.

J. Virol 73:3418–3423. Walev, I., J. Podlech, and D. Falke. 1995. Enhancement by TNF-α of reactivation and replication of latent herpes simplex virus from trigeminal ganglia of mice.

Arch. Virol 140:987–992. Carr, D. J J., S. Noisakran, W. P. Halford, N.

Lukacs, V. Asensio, and I. L. Campbell. 1998. Cytokine and chemokine production in HSV-1 latently infected trigeminal ganglion cell cultures: effects of hyperthermic stress. J.

Neuroimmunol 85:111–121. Hill, J. M., H. H. Garza, M. F. Helmy, S.

D. Cook, P. A. Osborne, E. M. Johnson, H. W.

Thompson, L. C. Green, R. J. O’Callaghan, and B. M. Gebhardt.

1997. Nerve growth factor antibody stimulates reactivation of ocular herpes simplex virus type 1 in latently infected rabbits. J. Neurovirol 3:206–211. Kreisel, J. D., B. M.

Gebhardt, J. M. Hill, S. A. Maulden, I. P. Hwang, T.

E. Clinch, X. Cao, S. L. Spruance, and B. A. Araneo.

1997. Anti-interleukin-6 antibodies inhibit herpes simplex virus reactivation. J. Infect. Dis 175:821–827. LeBlanc, R. A., L.

Pesnicak, E. S. Cabral, M. Godleski, and S. E. Straus. 1999.

Lack of interleukin-6 (IL-6) enhances susceptibility to infection but does not alter latency or reactivation of herpes simplex type 1 in IL-6 knockout mice. J. Virol 73:8145–8151. Keadel, T. L., N. Usui, K. A.

Laycock, J. K. Miller, J. S. Pepose, and P. M. Stuart.

2000. IL-1 and TNF-α in the pathogenesis of murine recurrent herpetic stromal keratitis. Investig. Ophthalmol. Vis. Sci 41:96–102. Kaufman, H.

E., E. D. Varnell, B. M. Gebhardt, H. W. Thompson, and J.

M. Hill. 1996. Propanolol suppression of ocular HSV-1 recurrence and associated corneal lesions following spontaneous reactivation in the rabbit. Curr. Eye Res 15:680–684. Sekizawa, T., H.

Openshaw, and A. L. Notkins. 1985. Site specificity of epithelial irritants in the reactivation of herpes simplex virus. J. Infect.

Dis 152:841–842.

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