Varicella-zoster virus: overview and clinical manifestations. – PubMed

Varicella-zoster virus: overview and clinical manifestations. - PubMed

Varicella-zoster virus: overview and clinical manifestations. - PubMed
Herpes zoster (or simply zoster), commonly known as shingles and also known as zona, is a viral disease characterized by a painful skin rash with blisters in a limited area on one side of the body, often in a stripe. To schedule an appointment, call the Student Health Service front desk at 412-383-1800 or the Office of Health Education & Promotion at 412-383-1830. A non-invasive, non-toxic approach to eliminate ‪#‎pain‬ and accelerate healing. Shingles called herpes zoster a painful skin disease that causes chicken pox like affects with bands of blisters on one side of the body. The typical shingles rash starts as redness followed by blisters that usually cover only one side of your body. Severe pain is the major cause of acute and chronic morbidity in patients with herpes zoster. The virus may spread from one or more ganglia along nerves of an affected segment and infect the corresponding dermatome (an area of skin supplied by one spinal nerve) causing a painful rash.Although the rash usually heals within two to four weeks, some sufferers experience residual nerve pain for months or years, a condition called postherpetic neuralgia.

The majority (70-80%) of these immune cells in the cerebrospinal fluid (CSF) are phenotypic CD3+ memory T-cells; both CD4+ and CD8+ subsets are present with around 40-50% and 20-30%, respectively 5 In contrast, B-cells (dominantly CD27+ memory cells), natural killer (NK) cells, dendritic cells (DCs), and perivascular and meningeal mast cells as well as monocytes and polymorphonuclear granulocytes (PMN) are only present in low numbers 6 – 8 However, the composition of inflammatory cells in the CNS and especially in the CSF, which can be clinically monitored by lumbar puncture, undergoes constant changes throughout a CNS infection. 2002;17(1):57-61.

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