Lichen planus is a relatively common papulosquamous skin disease of unknown etiology. After primary infection, HSV then establishes latency in sensory nerve ganglia and reactivates intermittently, precipitated by various factors. She had already been medicated with Valacyclovir and Acyclovir for 4 weeks, without clinical improvement. In a 2-year prospective study, 18 children with herpes zoster were clinically diagnosed in outpatient consultations in a hospital dermatology unit. (a) Zosteriform lesions for typical animals at the start of treatment (day 3 postinfection) and after 4 days of treatment (day 6 postinfection) with placebo, valacyclovir, or BAY 57-1293. Tzanck smears, biopsy specimens, and sera were obtained from 18, 4, and 10 children, respectively. The fourth (bottom) stick figure shows the double deletion that eliminates the C5/P blocking and the C3 binding domain.
Herpes simplex virus has developed many strategies for survival in the human host. Sequencing analyses were conducted on an ASP2151-resistant VZV mutant. Evidence for previous full-blown varicella and varicella with few lesions was recorded in 7 and 4 of the 17 immunocompetent children, respectively. No history of varicella was recalled in 6 of 17 cases, although a serologic clue of past varicella infection (IgM negative, IgG positive) was disclosed. Recurrent herpes zoster was diagnosed in one immunocompromised child. Zoster-associated pain was localized and the disease severity remained mild in all children. Established risk factors for childhood herpes zoster were only rarely found in our series of patients.
When LC appears, it is usually perceived as a sign of an unfavorable outcome, preceding blastic transformation. Zosteriform herpes simplex virus infections should be differentiated from childhood herpes zoster, emphasizing the importance of precise viral identification.