Zylet – Established Efficacy

Zylet - Established Efficacy

Bókay 1 was the first, three quarters of a century ago, to claim purely on clinical grounds that varicella and herpes zoster were caused apparently by the same agent. It is used in ophthalmic solution for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. Conventional teaching has emphasized risks of steroid treatment, but as with any medical therapy, use is always guided by determination of the risk-benefit profile,” said Dr. Oral antiviral drugs. Corticosteroids inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. In stubborn cases of anterior segment eye disease, systemic adrenocortical hormone therapy may be required. Also, effective healing of the corneal surface is more difficult if the tear film is suboptimal.

OMNIPRED® (prednisolone acetate ophthalmic suspension) is contraindicated in most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella, and also in mycobacterial infection of the eye and fungal diseases of ocular structures. Comments: -Shake well before using. IMPORTANT SAFETY INFORMATION ZYLET is contraindicated in most viral diseases of the cornea and conjunctiva, including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella, and also in mycobacterial infections of the eye and fungal diseases of ocular structures. Prolonged use of corticosteroids may result in glaucoma with damage to the optic nerve, and defects in visual acuity and fields of vision. Steroids should be used with caution in the presence of glaucoma. However, a steroid can be used in a pulse or intermittent regimen as needed as long as the patient is carefully monitored for side effects, including IOP elevation and secondary infection, particularly herpetic infection,” he said. However, the risk of high doses of steroids in elderly should always be taken into consideration.
Zylet - Established Efficacy

Prolonged use of corticosteroids may result in glaucoma with damage to the optic nerve, defects in visual acuity and fields of vision, and in posterior subcapsular cataract formation. It is not known whether this drug is excreted in human milk. If necessary, insert punctal plugs only after controlling the ocular surface inflammation. Use of ocular steroids may prolong the course and may exacerbate the severity of many viral infections of the eye (including herpes simplex). -Care should be taken not to discontinue therapy prematurely. If signs and symptoms fail to improve after 2 days, the patient should be re-evaluated. Employment of corticosteroid medication in the treatment of patients with a history of herpes simplex requires great caution.

Use of ocular steroids may prolong the course and exacerbate the severity of many viral infections of the eye (including herpes simplex). Available steroids vary in their potency and safety profiles, and these features determine proper drug selection. Cool zinc calamine application, as advocated earlier, is better avoided, as it promotes crust formation. If signs and symptoms fail to improve after two days, the patient should be re-evaluated. Reference: 1. Minimal use of toxic preservatives (such as BAK) is important. Keep out of the reach of children.

Curr Med Res Opin. 2008;24(1):287-296.

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